Francisco Zarco and the Federal 3 corridor
The closest thing the valley has to a center: the highway, the Museo de la Vid y el Vino, a gas station, and the large wineries on either side.
For a first visit, and for anyone who wants asphalt under them rather than depending on dirt roads for everything.
Keep in mind: It is the busiest and least charming stretch of the valley. You sleep near everything, but you do not sleep in the countryside.

